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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SOCS1 rabbit polyclonal antibody |
Gene Name: | Suppressor of cytokine signaling 1 |
Synonyms: | SOCS1, CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3, suppressor of cytokine signaling 1, TIP-3 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse SOCS1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Uniprot ID: | O35716, Q9QX78 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 500-1: 1500 | kidney, ovarian cancer, ovary, small intestine, uterus |
Background
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity).
Images
|
Immunohistochemistry of paraffin embedded mouse kidney using SOCS1 (GB11372) at dilution of 1:900 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse ovary using SOCS1 (GB11372) at dilution of 1:900 (400x lens) |
| Immunohistochemistry of paraffin embedded rat ovary using SOCS1 (GB11372) at dilution of 1:900 (400x lens) |
| Immunohistochemistry of paraffin embedded rat uterus using SOCS1 (GB11372) at dilution of 1:900 (400x lens) |
|
Immunofluorescence of paraffin embedded human ovarian cancer using SOCS1 (GB11372) at dilution of 1:500 (400x lens) |
|
Immunofluorescence of paraffin embedded mouse small intestine using SOCS1 (GB11372) at dilution of 1:500 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
