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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SOX2 rabbit polyclonal antibody |
Gene Name: | Transcription factor SOX-2 |
Synonyms: | ANOP3, MCOPS3, SRY-box 2, Sox2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse SOX2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: | P48432, P48431 |
Product Usage Information
IHC/IF | Human, Mouse, Rat | 1: 250-1: 1000 | brain, subcutaneous tumor, gall bladder |
Background
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
Images
| IHC analysis of sox2 (GB11249). |
| IHC analysis of sox2 (GB11249). |
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IF analysis of sox2 (GB11249). |
| IF analysis of sox2 (GB11249). Sample: Mouse colon (Paraffin), 4% PFA (G1101) 12-24h. Antigen retrieval: TE buffer (pH 9.0) (G1203),98°C,20min. Blocking buffer: 3% BSA in PBS (GC305010), RT, 30min. Primary antibody: 1: 500, 4°C overnight. Secondary antibody: Cy3 conjugated Goat Anti-Rabbit IgG (H+L) (GB21303), 1: 300 RT, 1h. |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
