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| Reactivity: | H,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Skp1 rabbit polyclonal antibody |
Gene Name: | S-phase kinase-associated protein 1 |
Synonyms: | Cyclin-A/CDK2-associated protein p19, S-phase kinase-associated protein 1A, p19A, p19skp1, Skp1, Skp1a |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Skp1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, cytoplasm |
Uniprot ID: | Q6PEC4 |
Images
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Rat | 1: 1500-1: 3000 | colon, heart, liver, lung |
Background
SKP1A is an F-box protein which functions as a substrate recognition component of the SCF ubiquitin ligase complex. It binds to cyclin F, S-phase kinase-associated protein 2, and other regulatory proteins involved in ubiquitin proteolysis through an F-box motif. SKP1A also collaborates with a network of proteins to control beta-catenin levels and affects the activity level of beta-catenin dependent TCF transcription factors. Studies have also characterized the protein as an RNA polymerase II elongation factor.
Images
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Immunohistochemistry of paraffin embedded rat heart using SKP1 (GB111230) at dilution of 1:1600 (400x lens) |
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Immunohistochemistry of paraffin embedded rat lung using SKP1 (GB111230) at dilution of 1:1600 (400x lens) |
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Immunofluorescence of paraffin embedded human colon using SKP1 (GB111230) at dilution of 1:1600 (400x lens) |
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Immunofluorescence of paraffin embedded human liver using SKP1 (GB111230) at dilution of 1:1600 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
