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Anti-Spata18 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Mitochondria-eating protein |
Synonyms: | Spata18, Mieap |
Immunogen: | Recombinant protein corresponding to Mouse SPATA18 |
Uniprot ID: | Q0P557 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Mitochondrion |
Product Usage Information
IHC/IF | Mouse, Rat | 1: 1500-1: 3000 | trachea |
Background
Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. May have a role in spermatogenesis, especially in cell differentiation from late elongate spermatids to mature spermatozoa (By similarity).
Images
| Immunohistochemistry analysis of paraffin embedded mouse trachea using SPATA18 (GB114445) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded rat trachea using SPATA18 (GB114445) at dilution of 1: 1000 |
| Immunofluorescence analysis of paraffin embedded mouse trachea using SPATA18 (GB114445) at dilution of 1: 1500 |
| Immunofluorescence analysis of paraffin embedded rat trachea using SPATA18 (GB114445) at dilution of 1: 1500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
