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| Reactivity: | H,M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TAU rabbit polyclonal |
| Gene Name: | Microtubule-associated protein tau |
| Synonyms: | Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, MAPT, DDPAC, FTDP 17, MAPTL, RNPTAU, PPP1R103, Paired helical filament-tau |
| Immunogen: | KLH conjugated Synthetic peptide corresponding to Human TAU |
| Isotype: | IgG |
| Purity: | Affinity purification |
| Subcellular location: | Cytoplasm, Cell membrane |
| Predicted MW. | 79 kDa |
| Observed MW. | 50-80 kDa |
| Uniprot ID: | P10636, P10637, P19332 |
Product Usage Information
WB | Human, Mouse, Rat | 1: 2000-1: 4000 | brain, cortex, spinal cord, hippocampus |
IHC/IF | Human, Mouse, Rat | 1: 3000-1: 5000 | gliomas, brain |
Background
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome.
Images
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Western blot analysis of TAU (GB111608) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded human gliomas using TAU (GB111608) at dilution of 1: 3000 |
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Immunohistochemistry analysis of paraffin-embedded mouse brain using TAU (GB111608) at dilution of 1: 3000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |