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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TDP1 rabbit polyclonal antibody |
Gene Name: | Tyrosyl-DNA phosphodiesterase 1 |
Synonyms: | Tyr-DNA phosphodiesterase 1, Protein expressed in male leptotene and zygotene spermatocytes 501, MLZ-501, Tdp1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse TDP1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 69 kDa |
Observed MW. | 69 kDa |
Uniprot ID: | Q8BJ37, Q4G056 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 500-1: 1000 | stomach, liver, kidney |
Background
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1).
Images
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Western blot analysis of TDP1 (GB111302) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |