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| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TFPI rabbit polyclonal antibody |
Gene Name: | Tissue factor pathway inhibitor |
Synonyms: | EPI, Extrinsic pathway inhibitor, LACI, TFI, TFPI, TFPI1, Lipoprotein-associated coagulation inhibitor |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse TFPI |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
IHC/IF | Human, Mouse, Rat | 1: 500-1: 1000 | esophageal cancer, brain, lung |
Background
Tissue factor pathway inhibitor (TFPI) is a critical anticoagulant protein present in endothelium and platelets. TFPI is produced as two major isoforms in humans, TFPIa and TFPIb that result from alternative splicing. The TFPIb isoform localizes to the endothelium surface where it is a potent inhibitor of tissue factor-factor VIIa complexes that initiate blood coagulation. The TFPIa isoform is present in platelets. TFPI is a Kunitz-type serine protease inhibitor that exerts anticoagulant activity by blocking early procoagulant stimulia. TFPI can enhance anti-thrombotic treatment in sepsis, inflammatory diseases, and cardiovascular diseases.
Images
 | Immunohistochemistry analysis of paraffin embedded human esophageal carcinoma using TFPI (GB113817) at dilution of 1: 600 |
 | Immunohistochemistry analysis of paraffin embedded mouse lung using TFPI (GB113817) at dilution of 1: 600 |
| Immunofluorescent analysis of paraffin embedded rat brain using TFPI (GB113817) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
