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Anti-TIMP1 Rabbit pAb (100 μl)
| Reactivity: | H & H |
| Applications: | IHC/IF & ICC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Metalloproteinase inhibitor 1 |
Synonyms: | CLGI, EPO, TIMP |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human TIMP1 |
Uniprot ID: | P01033 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted |
Product Usage Information
IHC/IF | Human | 1: 600-1: 1200 | lung cancer, liver cancer, breast cancer |
ICC/IF | Human | 1: 100-1: 400 | HeLa |
Background
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
Images
| Immunohistochemistry analysis of paraffin embedded human lung cancer using TIMP1 (GB115312) at dilution of 1:1200 |
| Immunohistochemistry analysis of paraffin embedded human liver cancer using TIMP1 (GB115312) at dilution of 1:1200 |
| Immunohistochemistry analysis of paraffin embedded human breast cancer using TIMP1 (GB115312) at dilution of 1:1200 |
| Immunohistochemistry analysis of paraffin embedded human breast cancer using TIMP1 (GB115312) at dilution of 1:1200 |
| Immunocytochemistry analysis of 4% paraformaldehyde-fixed HeLa cells using TIMP1(GB115312) at dilution of 1:100-1:400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
