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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TLR9 rabbit polyclonal |
Gene Name: | Toll-like receptor 9 |
Synonyms: | TLR9, CD289, toll like receptor 9, Toll like receptor 9 isoform A precursor, Toll like receptor 9 isoform B |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse TLR9 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Lysosome, Membrane |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human, Mouse | 1: 100-1: 500 | tonsil, spleen |
IF | Human, Mouse | 1: 100-1: 500 | tonsil, spleen |
Background
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response . Controls lymphocyte response to Helicobacter infection (By similarity).
Images
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Immunohistochemistry analysis of paraffin-embedded human tonsil using TLR9(GB11266) at dilution of 1:200 |
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Immunohistochemistry analysis of paraffin-embedded mouse spleen using TLR9(GB11266) at dilution of 1:400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
