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Anti-TNFAIP1 Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 |
Synonyms: | B12, B61, BACURD2, EDP1, hBACURD2, Protein B12, TNFAIP1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse TNFAIP1 |
Uniprot ID: | O70479 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 36 kDa / 36 kDa |
Product Usage Information
WB | Human | 1: 500-1: 800 | HUVEC, Jurkat, HeLa |
Background
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity (By similarity).
Images
| Western blot analysis of TNFAIP1 (GB114574) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
