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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TNR rabbit polyclonal |
Gene Name: | Tenascin-R |
Synonyms: | TN-R, Janusin, Neural recognition molecule J1-160/180, Restrictin, Tnr |
Immunogen: | Recombinant protein corresponding to Mouse TNR |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 150 kDa |
Observed MW. | 170 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 300-1: 600 | pancreas, cerebellum, brain |
Background
TNR, also named as Restrictin and Janusin, belongs to the tenascin family. Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides, TNR inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2 (FAK) phosphorylation and cell detachment.
Images
Western blot analysis of TNR (GB112795) at dilution of 1: 600 Lane 1: U87 cell lysate Lane 2: THP-1 cell lysate Lane 4: Mouse pancreas tissue lysate Lane 5: Mouse cerebellum tissue lysate Lane 6: Rat brain tissue lysate Lane 7: Rat pancreas tissue lysate | |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
