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Anti-TRIM7 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | E3 ubiquitin-protein ligase TRIM7 |
Synonyms: | Glycogenin interacting protein, GNIP, RING finger protein 90, RNF90, TRIM7, tripartite motif containing 7 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse TRIM7 |
Uniprot ID: | Q923T7 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 57 kDa / 57 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 300-1: 800 | heart, skeletal muscle |
Background
E3 ubiquitin-protein ligase . Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation . Promotes the TLR4-mediated signaling activation through its E3 ligase domain leading to production of proinflammatory cytokines and type I interferon . Plays also a negative role in the regulation of exogenous cytosolic DNA virus-triggered immune response. Mechanistically, enhances the 'Lys-48'-linked ubiquitination of STING1 leading to its proteasome-dependent degradation .
Images
| Western blot analysis of TRIM7 (GB114596) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
