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Anti-TRIM71/LIN41 Rabbit pAb (100 μl)
| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | E3 ubiquitin-protein ligase TRIM71 |
Synonyms: | LIN41, Protein lin 41 homolog, TRIM71, tripartite motif containing 71 |
Immunogen: | Recombinant protein corresponding to Mouse TRIM71/LIN41 |
Uniprot ID: | Q1PSW8 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 92 kDa / 92 kDa |
Product Usage Information
WB | Mouse | 1: 500-1: 1000 | NIH/3T3 |
Background
E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1. Specific regulator of miRNA biogenesis. miRNA Binds MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression.
Images
| Western blot analysis of TRIM71 (GB115356) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
