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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Tumor susceptibility gene 101 protein |
Synonyms: | Cell and organelle markers, ESCRT I complex subunit TSG101, Exosome marker, TSG10, TSG101, VPS23 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human TSG101 |
Uniprot ID: | Q61187 |
Isotype: | IgG2a,κ |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 44KDa / 44/46 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 500-1: 1000 | heart |
Background
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity).It may also play a role in the extracellular release of microvesicles that differ from the exosomes (By similarity).
Images
| Western blot analysis of TSG101 (GB12619) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
