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| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TXN rabbit polyclonal |
Gene Name: | Thioredoxin |
Synonyms: | ADF, ATL-derived factor, SASP, TRDX, TRX, TRX1, TXN, Surface-associated sulphydryl protein, Hom s Trx |
Immunogen: | Recombinant protein corresponding to Human TXN |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 12 kDa |
Observed MW. | 12 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human | 1: 300-1: 1000 | HeLa, HepG2, Jurkat, MCF-7, K562, Raji, NCI-H460 |
Background
TXN, TRDX, TRX, TRX1, ADF and SASP, belongs to the thioredoxin family. It participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. TXN plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. TXN induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.
Images
 | Western blot analysis of TXN (GB113567) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
