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Anti-Thyroglobulin Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Thyroglobulin rabbit polyclonal |
Gene Name: | Thyroglobulin |
Synonyms: | AITD3, TG, TGN |
Immunogen: | Recombinant protein corresponding to Mouse Thyroglobulin |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 3000-1: 6000 | thyroid gland |
Background
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.
Images
| Immunohistochemistry analysis of paraffin-embedded mouse thyroid gland using TG (GB113301) at dilution of 1: 6000 |
| Immunohistochemistry analysis of paraffin-embedded rat thyroid gland using TG (GB113301) at dilution of 1: 6000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
