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Anti-Tollip Rabbit pAb (100 μl)
| Reactivity: | M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Tollip rabbit polyclonal antibody |
Gene Name: | Toll-interacting protein |
Synonyms: | TOLLIP, IL-1RAcPIP, toll interacting protein |
Immunogen: | Recombinant protein corresponding to Mouse Tollip |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Predicted MW. | 30 kDa |
Observed MW. | 30 kDa |
Uniprot ID: | Q9H0E2, Q9QZ06 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 500-1: 1000 | brain, spleen, thymus |
IHC/IF | Human, Mouse, Rat | 1: 500-1: 2000 | brain, kidney, liver cancer, lung, spleen |
Background
The Tollip is the component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates.
Images
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Western blot analysis of tolip (GB111093) at dilution of 1: 500 |
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Immunohistochemistry of paraffin embedded human liver cancer using tollip (GB111093) at dilution of 1: 2200 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse lung using tollip (GB111093) at dilution of 1: 2200 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse spleen using tollip (GB111093) at dilution of 1: 2200 (400x lens) |
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Immunohistochemistry of paraffin embedded rat brain using tollip (GB111093) at dilution of 1: 2200 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat kidney using tollip (GB111093) at dilution of 1: 2200 (400x lens) |
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Immunohistochemistry of paraffin embedded rat spleen using tollip (GB111093) at dilution of 1: 2200 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
