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Anti-UACA/Nucling Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Uveal autoantigen with coiled-coil domains and ankyrin repeats |
Synonyms: | KIAA1561, NUCLING, UACA |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse UACA/Nucling |
Uniprot ID: | Q8CGB3 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Product Usage Information
IHC/IF | Human | 1: 600-1: 1200 | breast cancer, renal carcinoma, endometrial cancer |
Background
Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1. ; Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation .
Images
| Immunohistochemistry analysis of paraffin embedded human renal carcinoma using UACA (GB114733) at dilution of 1: 600 |
| Immunohistochemistry analysis of paraffin embedded human breast cancer using UACA (GB114733) at dilution of 1: 600 |
| Immunohistochemistry analysis of paraffin embedded human endometrial Cancer using UACA (GB114733) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
