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Anti-UAP1L1 Rabbit pAb (100 μl)
| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | UAP1L1 rabbit polyclonal antibody |
Gene Name: | UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 |
Synonyms: | Uap1l1, UDP N acteylglucosamine pyrophosphorylase 1 like 1 |
Immunogen: | Recombinant protein corresponding to Mouse UAP1L1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 57 kDa |
Observed MW. | 57 kDa |
Uniprot ID: | Q3TW96 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse | 1: 2000-1: 4000 | pancreas, kidney, skin |
Background
UAP1 is a 56KDa isoform which catalyzes the final step of UDP-N-acetylglucosamine (UDP-GlcNAc) biosynthesis from fructose-6-phosphate. UDP-GlcNAc, the activated form of GlcNAc moiety is used as a key precursor in N-linked glycosylation and the glycosylphosphatidylinositol (GPI)-anchor of cellular proteins. Crystallization studies revealed UAP1 is composed of a large central core flanked by two smaller extra domains. The central main domain displays a alpha/beta structure resembling the Rossmann fold. Northern Blot analysis detected abundant expression of UAP1 in testis and sperm with a low expression in placenta, muscle and liver. It is implicated in antibody-mediated infertility in males.
Images
 | Western blot analysis of UAP1L1 (GB112664) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
