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Anti-UVRAG Rabbit pAb (100 μl)
| Reactivity: | H,M & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | UV radiation resistance-associated protein |
Synonyms: | DHTX , Beclin 1 binding protein, p63, VPS38, Disrupted in heterotaxy |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse UVRAG |
Uniprot ID: | Q8K245 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Centromere, Chromosome, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Lysosome |
Predicted MW. / Observed MW. | 78 kDa / 100 kDa |
Product Usage Information
WB | Human, Mouse | 1: 800-1: 1500 | HeLa, A20 |
IHC/IF | Human | 1: 500-1: 1000 | esophageal carcinoma, endometrial cancer |
Background
Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P). During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3.
Images
| Western blot analysis of UVRAG (GB114718) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human esophageal carcinoma using UVRAG (GB114718) at dilution of 1: 500 |
| Immunohistochemistry analysis of paraffin embedded human endometrial cancer using UVRAG (GB114718) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
