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Anti-VPS35 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Vacuolar protein sorting-associated protein 35 |
Synonyms: | hVPS35, Maternal embryonic 3, MEM3, Vesicle protein sorting 35, VPS35 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse VPS35 |
Uniprot ID: | Q9EQH3 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 92 kDa / 95 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 1000-1: 2000 | spleen, brain, lung |
Background
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC.
Images
| Western blot analysis of VPS35 (GB114681) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
