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| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | VR1 rabbit polyclonal antibody |
Gene Name: | Transient receptor potential cation channel subfamily V member 1 |
Synonyms: | TrpV1, Capsaicin receptor, Osm-9-like TRP channel 1, OTRPC1, Vanilloid receptor 1, VR1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse VR1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 95 kDa |
Observed MW. | 95 kDa |
Uniprot ID: | Q8NER1 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human | 1: 500-1: 1000 | Hacat, T-47D, PC12 |
Background
TRPV1 is a nonselective cation channel that resembles members of the transient receptor potential (TRP) family of ion channels. Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accubens by affecting AMPA receptors endocytosis.
Images
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Western blot analysis of TRPV1 (GB111088) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
