Your shopping cart is empty!
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Serine/threonine-protein kinase VRK1 |
Synonyms: | vaccinia related kinase 1, VRK1 |
Immunogen: | Recombinant protein corresponding to Mouse VRK1 |
Uniprot ID: | Q80X41 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 50 kDa / 48 kDa |
Product Usage Information
WB | Human | 1: 300-1: 500 | HeLa |
Background
Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm.
Images
| Western blot analysis of VRK1 (GB114547) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
