Your shopping cart is empty!
Anti-WDR77 Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Methylosome protein 50 |
Synonyms: | Androgen receptor cofactor p44, HKMT1069, MEP 50, MEP50, Methylosome protein 50, Nbla10071, p44, p44/Mep50, RP11 552M11.3, WD repeat domain 77 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse WDR77 |
Uniprot ID: | Q99J09 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 37 kDa / 40 kDa |
Product Usage Information
WB | Human | 1: 1000-1: 2000 | 293T, Jurkat |
Background
Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.
Images
| Western blot analysis of WDR77 (GB115073) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
