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Anti-WDR81 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | WDR81 rabbit polyclonal antibody |
Gene Name: | WD repeat-containing protein 81 |
Synonyms: | Wdr81 |
Immunogen: | Recombinant protein corresponding to Mouse WDR81 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Endosome, Lysosome, Membrane, Mitochondrion, Cytoplasm, Cytoplasmic vesicle |
Predicted MW. | 212 kDa |
Observed MW. | 65 kDa |
Uniprot ID: | Q562E7, Q5ND34, D4A929 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 1000-1: 2000 | brain, cerebellum |
IHC/IF | Mouse, Rat | 1: 700-1: 1400 | brain, corpus striatum, rectum |
Background
This gene functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates.
Images
 | Western blot analysis of WDR81 (GB112651) at dilution of 1: 1000 |
 | Immunofluorescence of paraffin embedded mouse corpus striatum using WDR81 (GB112651) at dilution of 1: 700 (400x lens) |
 | Immunofluorescence of paraffin embedded mouse rectum using WDR81 (GB112651) at dilution of 1: 700 (400x lens) |
 | Immunofluorescence of paraffin embedded rat brain using WDR81 (GB112651) at dilution of 1: 700 (200x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
