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| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Pre-mRNA-splicing factor SYF1 |
Synonyms: | HCNP, HCRN, KIAA1177, NTC90, Pre mRNA splicing factor SYF1, Protein HCNP, SYF1, XAB2, XPA binding protein 2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse XAB2 |
Uniprot ID: | Q9DCD2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Product Usage Information
IHC/IF | Mouse, Rat | 1: 1500-1: 3000 | testis |
Background
XPA-binding protein 2 (XAB2) a tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription. XAB2 is involved in pre-mRNA splicing, transcription, and transcription-coupled DNA repair, leading to preimplantation lethality, and is essential for mouse embryogenesis. It interactes with Cockayne syndrome groups A and B (CSA and CSB) proteins and RNA polymerase II, which are known to be involved in transcription-coupled repair (TCR) and transcription, and that the antibodies against XAB2 protein inhibited the recovery of RNA synthesis after UV irradiation and normal RNA synthesis when microinjected into living fibroblasts.
Images
| Immunohistochemistry analysis of paraffin embedded mouse testis using XAB2 (GB114137) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin embedded rat testis using XAB2 (GB114137) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin embedded rat tsetis using XAB2 (GB114137) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
