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Anti-c-kit Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Mast/stem cell growth factor receptor Kit |
Synonyms: | C Kit, CD117, c-Kit, KIT, PBT, Proto-oncogene c-Kit, SCFR, Tyrosine protein kinase Kit, Sl |
Immunogen: | Recombinant protein corresponding to Human C-Kit |
Uniprot ID: | P10721 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Product Usage Information
IHC/IF | Human | 1: 250-1: 500 | gastrointestinal stromal tumor, colon cancer, seminoma |
Background
KIT, also named as SCFR, c-Kit and CD117, is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. It is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand(SCF) binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Phosphorylation at tyrosine 721 of KIT allows binding and activation of PI3 kinase.
Images
| Immunohistochemistry analysis of paraffin embedded human colon cancer using c-kit (GB114580) at dilution of 1: 500 |
| Immunohistochemistry analysis of paraffin embedded human gastrointestinal stromal tumor using c-kit (GB114580) at dilution of 1: 500 |
| Immunohistochemistry analysis of paraffin embedded human seminoma using c-kit (GB114580) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
