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| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Sin3b rabbit polyclonal antibody |
Gene Name: | Paired amphipathic helix protein Sin3b |
Synonyms: | Sin3b, SIN3B, Paired amphipathic helix protein Sin3b, SIN3 transcription regulator family member B |
Immunogen: | Recombinant protein corresponding to Mouse Sin3b |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: | Q62141 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 500-1: 1000 | testis |
Background
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.
Images
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Immunohistochemistry of paraffin embedded mouse testis using sin3b (GB11927) at dilution of 1:600 (300x lens) |
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Immunofluorescence of paraffin embedded rat testis using sin3b (GB11927) at dilution of 1:500 (200x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
