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| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Homeobox protein SIX3 |
Synonyms: | HPE2, Sine oculis homeobox homolog 3, SIX homeobox 3 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Six3 |
Uniprot ID: | Q62233 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 36 kDa / 37 kDa |
Product Usage Information
WB | Human, Mouse | 1: 100-1: 300 | C2C12, SH-SY5Y, 293T |
Background
Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon . Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression . In addition, Six3 activity is required for the formation of the telencephalon.Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 AND CCND2 .
Images
| Western blot analysis of SIX3 (GB114815) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
