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| Reactivity: | H,M,R & H,M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Src rabbit polyclonal |
Gene Name: | Neuronal proto-oncogene tyrosine-protein kinase Src |
Synonyms: | SRC, ASV, SRC1, c-p60-Src, SRC proto-oncogene, non receptor tyrosine kinase, THC6 |
Immunogen: | Recombinant protein corresponding to Mouse Src |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membranem, Cytoplasm, Nucleus |
Uniprot ID: | P12931, P05480, Q9WUD9 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human, Mouse, Rat | 1: 1000-1: 4000 | breast cancer, brain, small intestine |
IF | Human, Mouse, Rat | 1: 500-1: 1000 | breast cancer, brain, small intestine |
Background
SRC, also named as SRC1 and p60-Src, belongs to the protein kinase super family, Tyr protein kinase family and SRC subfamily. It is a non-receptor protein tyrosine kinase that plays pivotal roles in numerous cellular processes such as proliferation, migration, and transformation. In concert with PTK2B, SRC plays an important role in osteoclastic bone resorption. It promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
Images
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Immunohistochemistry analysis of paraffin-embedded human breast cancer using Src (GB111035) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded mouse brain using Src (GB111035) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded mouse small intestine using Src (GB111035) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded rat brain using Src (GB111035) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
