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| Reactivity: | M,R & M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Src rabbit polyclonal |
Gene Name: | Proto-oncogene tyrosine-protein kinase Src |
Synonyms: | SRC, ASV, SRC1, c-p60-Src, SRC proto-oncogene, non-receptor tyrosine kinase, THC6 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Src |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membranem, Cytoplasm, Nucleus |
Uniprot ID: | P05480, Q9WUD9 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 1000-1: 2500 | substantia nigra, corpus striatum |
IF | Mouse, Rat | 1: 500-1: 1000 | substantia nigra, corpus striatum |
Background
Proto-oncogene tyrosine-protein kinase Src is a non-receptor tyrosine kinase protein encoded by the SRC gene. This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
Images
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Immunohistochemistry analysis of paraffin-embedded mouse substantia nigra using Src (GB11783) at dilution of 1: 1200 |
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Immunohistochemistry analysis of paraffin-embedded rat substantia nigra using Src (GB11783) at dilution of 1: 1200 |
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Immunohistochemistry analysis of paraffin-embedded rat corpus striatum using Src (GB11783) at dilution of 1: 1200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |