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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Calcineurin B homologous protein 3 |
Synonyms: | CHP3, TESC, tescalcin, TSC |
Immunogen: | Recombinant protein corresponding to Mouse TESC |
Uniprot ID: | Q9JKL5 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 25 kDa / 25 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 2000-1: 4000 | heart, brain, cerebellum, kidney |
Background
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.
Images
| Western blot analysis of TESC (GB114370) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
