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Anti-THEM4 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | THEM4 rabbit polyclonal antibody |
Gene Name: | Acyl-coenzyme A thioesterase THEM4 |
Synonyms: | Acyl-CoA thioesterase THEM4, Them4, Ctmp, Carboxyl-terminal modulator protein, Thioesterase superfamily member 4 |
Immunogen: | Recombinant protein corresponding to Mouse THEM4 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Cytoplasm |
Uniprot ID: | Q3UUI3 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1:200-1:400 | brain, kidney, testis |
Background
THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer.
Images
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Immunohistochemistry of paraffin embedded mouse brain using ctmp (GB111324) at dilution of 1:200 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse kidney using ctmp (GB111324) at dilution of 1:200 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse testis using ctmp (GB111324) at dilution of 1:200 (400x lens) |
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Immunohistochemistry of paraffin embedded rat brain using ctmp (GB111324) at dilution of 1:200 (400x lens) |
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Immunohistochemistry of paraffin embedded rat kidney using ctmp (GB111324) at dilution of 1:200 (400x lens) |
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Immunohistochemistry of paraffin embedded rat testis using ctmp (GB111324) at dilution of 1:200 (400x lens) |
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Immunofluorescence of paraffin embedded mouse kidney using ctmp (GB111324) at dilution of 1:200 (400x lens) |
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Immunofluorescence of paraffin embedded rat testis using ctmp (GB111324) at dilution of 1:200 (300x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
