Your shopping cart is empty!
| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TLR4 rabbit polyclonal |
Gene Name: | Toll-like receptor 4 |
Synonyms: | TLR4, ARMD10, CD284, TLR-4, TOLL, toll like receptor 4 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse TLR4 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human, Rat | 1: 500-1: 1000 | tonsil, spleen Lymph node |
IF | Human, Rat | 1: 500-1: 1000 | tonsil, spleen Lymph node |
Background
TLR4 is a transmembrane protein, member of the toll-like receptor family, which belongs to the pattern recognition receptor (PRR) family. Its activation leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system.It is most well known for recognizinglipopolysaccharide (LPS), a component present in many Gram-negative bacteria (e.g. Neisseria spp.) and selectGram-positive bacteria. Its ligands also include several viral proteins, polysaccharide, and a variety of endogenous proteins such as low-density lipoprotein, beta-defensins, and heat shock protein.
Images
|
|
Immunohistochemistry analysis of paraffin-embedded human tonsil using TLR4(GB11186) at dilution of 1:1000 |
|
|
Immunohistochemistry analysis of paraffin-embedded rat lymph node using TLR4(GB11186) at dilution of 1:1000 |
|
|
Immunohistochemistry analysis of paraffin-embedded rat spleen using TLR4(GB11186) at dilution of 1:1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
