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Anti-TNF Receptor II Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TNF Receptor II rabbit polyclonal antibody |
Gene Name: | Tumor necrosis factor receptor superfamily member 1B |
Synonyms: | Tumor necrosis factor receptor 2, TNFR2, P75, Tumor necrosis factor receptor type II, TNFRII, P80 TNF-alpha receptor, CD120b, Etanercept, TBP-2, TBPII, TNFRSF1B, TNFBR |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse TNF Receptor II |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 48 kDa |
Observed MW. | 73 kDa |
Uniprot ID: | P20333, P25119, Q80WY6 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain, cerebral cortex, spleen, cerebellum, spinal cord |
Background
The protein encoded by this gene is a member of the TNF-receptor super family. This protein and TNF-receptor 1 form a hetero complex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
Images
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Western blot analysis of TNFRSF1B(M) (GB111014) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
