Your shopping cart is empty!
Anti-TRIM23/ARD1 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | E3 ubiquitin-protein ligase TRIM23 |
Synonyms: | ARD1, ARFD1, GTP binding protein ARD 1, RING finger protein 46, RNF46, TRIM23, tripartite motif containing 23 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse TRIM23/ARD1 |
Uniprot ID: | Q8BGX0 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 64 kDa / 72 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 500-1: 1000 | brain, lung |
Background
Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes.
Images
| Western blot analysis of TRIM23 (GB114770) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
