Your shopping cart is empty!
Anti-TRPV4 Rabbit pAb (100 μl)
| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TRPV4 rabbit polyclonal antibody |
Gene Name: | Transient receptor potential cation channel subfamily V member 4 |
Synonyms: | TrpV4, Osm-9-like TRP channel 4, OTRPC4, Transient receptor potential protein 12, TRP12, Vanilloid receptor-like protein 2, VR-OAC |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse TRPV4 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 98 kDa |
Observed MW. | 98 kDa |
Uniprot ID: | Q9EPK8 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse | 1: 500-1: 1000 | heart |
Background
TRPV4 is a cation-selective channel, activated in response to systemic osmotic pressure. FUNCTION: Non-selective calcium permanent cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. SUBUNIT, Interacts with calmodulin. Interacts with Map7 and Src family Tyr protein kinases LYN, SRC, FYN, HCK, LCK and YES.
Images
|
|
Western blot analysis of TRPV4 (GB111107) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
