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Anti-TopBP1 Rabbit pAb (100 μl)
| Reactivity: | H,R & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | DNA topoisomerase 2-binding protein 1 |
Synonyms: | KIAA0259, TOP2BP1, TOPBP1 |
Immunogen: | Recombinant protein corresponding to Mouse TOPBP1 |
Uniprot ID: | Q6ZQF0 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm, Cytoskeleton |
Predicted MW. / Observed MW. | 169 kDa / 170-200 kDa |
Product Usage Information
WB | Human, Rat | 1: 300-1: 500 | testis |
IHC/IF | Human | 1: 2000-1: 4000 | placenta |
Background
Required for DNA replication (By similarity). Plays a role in the rescue of stalled replication forks and checkpoint control . Binds double-stranded DNA breaks and nicks as well as single-stranded DNA (By similarity). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage (By similarity). Induces a large increase in the kinase activity of ATR (By similarity)..
Images
| Western blot analysis of TOPBP1 (GB114364) at dilution of 1: 500 |
| Immunohistochemistry analysis of paraffin embedded human placenta using TOPBP1 (GB114364) at dilution of 1: 3000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
