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| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | UBR1 rabbit polyclonal antibody |
Gene Name: | E3 ubiquitin-protein ligase UBR1 |
Synonyms: | N-recognin-1, RING-type E3 ubiquitin transferase UBR1, Ubiquitin-protein ligase E3-alpha-1, Ubiquitin-protein ligase E3-alpha-I, Ubr1 |
Immunogen: | Recombinant protein corresponding to Mouse UBR1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 200 kDa |
Observed MW. | 200 kDa |
Uniprot ID: | Q8IWV7, O70481 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse | 1: 500-1: 1000 | skeletal muscle, liver |
Background
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
Images
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Western blot analysis of UBR1 (GB111477) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
