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| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | ULK1 rabbit polyclonal antibody |
Gene Name: | Serine/threonine-protein kinase ULK1 |
Synonyms: | ULK1, ATG1, ATG1A, UNC51, Unc51.1, hATG1, unc-51 like autophagy activating kinase 1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse ULK1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Uniprot ID: | O70405 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 500-1: 2000 | liver, lung |
Background
ULK1 belongs to the serine/threonine protein kinase family. It is involved in axon growth and plays an essential role in neurite branching during sensory axon outgrowth. Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity.
Images
 | Immunohistochemistry of paraffin embedded mouse liver using ULK1 (GB11580) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse lung using ULK1 (GB11580) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded rat liver using ULK1 (GB11580) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded rat lung using ULK1 (GB11580) at dilution of 1:1000 (400x lens) |
Storage
| Storage |
Store at -20°C for one year. Avoid repeated freeze/thaw cycles |
| Storage Buffer |
PBS with 0.02%sodium azide, 100 μg/ml BSA and 50% glycerol. |
