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| Reactivity: | H,M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Vesicle-associated membrane protein-associated protein A |
Synonyms: | 33 kDa VAMP associated protein, hVAP 33, VAMP A, VAMP associated protein A, VAP 33, VAP A, VAP33, VAPA |
Immunogen: | Recombinant protein corresponding to Mouse VAPA |
Uniprot ID: | Q9WV55 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Endoplasmic reticulum membrane, Cell membrane, Cell junction |
Predicted MW. / Observed MW. | 28 kDa / 34 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 2000-1: 3000 | kidney, brain, colon |
IHC/IF | Human, Mouse, Rat | 1: 800-1: 2400 | colon, stomach |
Background
Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking.
Images
| Western blot analysis of VAPA (GB114527) at dilution of 1: 2000 |
| Immunohistochemistry of paraffin embedded rat colon using VAPA (GB114527) at dilution of 1: 2400 |
| Immunohistochemistry of paraffin embedded mouse stomach using VAPA (GB114527) at dilution of 1: 2400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
