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| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Chromobox protein homolog 7 |
Synonyms: | Chromobox homolog 7 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse cbx7 |
Uniprot ID: | Q8VDS3 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 18 kDa / 30 kDa |
Product Usage Information
WB | Mouse | 1: 800-1: 2000 | liver |
Background
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Binds non-coding, single-stranded RNA and double-stranded RNA. Plays a role in the timely repression of differentiation-specific genes in pluripotent embryonic stem cells to maintain the undifferentiated state. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.
Images
| Western blot analysis of CBX7 (GB114894) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
