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Anti-gamma Catenin Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Junction plakoglobin |
Synonyms: | γ-Catenin, ARVD12, Catenin gamma, CTNNG, Desmoplakin 3, Desmoplakin III, DP3, DPIII, junction plakoglobin, JUP, gamma Catenin, PDGB, PKGB |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse gamma Catenin |
Uniprot ID: | Q02257 |
Isotype: | lgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 82 kDa / 82 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 300-1: 500 | heart |
Background
Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
Images
| WB analysis of JUP (GB115511). |
| WB analysis of JUP (GB115511). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
