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| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | keap1 rabbit polyclonal antibody |
Gene Name: | Kelch-like ECH-associated protein 1 |
Synonyms: | keap1, INrf2, KLHL19, Kelch like ECH associated protein 1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse keap1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Uniprot ID: | Q9Z2X8, Q14145, P57790 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 750-1: 3000 | breast cancer, colon, liver, Skeletal muscle, skin, small intestine, uterus |
Background
Keap1 has been shown to interact with Nrf2, a master regulator of the antioxidant response, which is important for the amelioration of oxidative stress. Under quiescent conditions, Nrf2 is anchored in the cytoplasm through binding to Keap1, which in turn facilitates the ubiquitination and subsequent proteolysis of Nrf2. Such sequestration and further degradation of Nrf2 in the cytoplasm are mechanisms for the repressive effects of Keap1 on Nrf2.
Images
 | Immunohistochemistry of paraffin embedded human breast cancer using keap1 (GB11847) at dilution of 1:3000 (300x lens) |
 | Immunohistochemistry of paraffin embedded human colon using keap1 (GB11847) at dilution of 1:1500 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse liver using keap1 (GB11847) at dilution of 1:3000 (300x lens) |
 | Immunohistochemistry of paraffin embedded mouse colon using keap1 (GB11847) at dilution of 1:1200 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse uterus using keap1 (GB11847) at dilution of 1:1200 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat small intestine using keap1 (GB11847) at dilution of 1:1200 (400x lens) |
 | Immunofluorescence of paraffin embedded human breast cancer using keap1 (GB11847) at dilution of 1:1500 (400x lens) |
 | Immunofluorescence of paraffin embedded mouse skin using nfatc1 (GB11847) at dilution of 1:800 (300x lens) |
 | Immunofluorescence of paraffin embedded mouse colon using keap1 (GB11847) at dilution of 1:1500 (400x lens) |
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Immunofluorescence of paraffin embedded mouse liver using keap1 (GB11847) at dilution of 1:1500 (400x lens) |
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Immunofluorescence of paraffin embedded rat colon using keap1 (GB11847) at dilution of 1:1500 (400x lens) |
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Immunofluorescence of paraffin embedded rat Skeletal muscle using keap1 (GB11847) at dilution of 1:1500 (400x lens) |
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Immunofluorescence of paraffin embedded rat uterus using keap1 (GB11847) at dilution of 1:1500 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
