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Anti-p115-RhoGEF Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | p115-RhoGEF rabbit polyclonal antibody |
Gene Name: | Rho guanine nucleotide exchange factor 1 |
Synonyms: | Lbc's second cousin, Lymphoid blast crisis-like 2, Arhgef1, Lbcl2, Lsc, p115RhoGEF, GEF1, LBCL2LSC |
Immunogen: | Recombinant protein corresponding to Mouse p115-RhoGEF |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Membrane |
Uniprot ID: | Q92888, Q61210, Q9Z1I6 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 500-1: 4000 | lymph node, spleen, thymus, thyroid gland |
Background
This protein seems to play a role in the regulation of RhoA GTPase by guanine nucleotide binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.
Images
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Immunohistochemistry of paraffin embedded human thyroid gland using Arhgef1 (GB111024) at dilution of 1:2000 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse lymph node using Arhgef1 (GB111024) at dilution of 1:2000 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse spleen using Arhgef1 (GB111024) at dilution of 1:2000 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse thymus using Arhgef1 (GB111024) at dilution of 1:2000 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat lymph node using Arhgef1 (GB111024) at dilution of 1:2000 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat spleen using Arhgef1 (GB111024) at dilution of 1:2000 (400x lens) |
 | Immunofluorescence of paraffin embedded human lymph node using Arhgef1 (GB111024) at dilution of 1:2000 (400x lens) |
 | Immunofluorescence of paraffin embedded human thyroid gland using Arhgef1 (GB111024) at dilution of 1:2000 (400x lens) |
 | Immunofluorescence of paraffin embedded mouse lymph node using Arhgef1 (GB111024) at dilution of 1:2000 (400x lens) |
 | Immunofluorescence of paraffin embedded rat spleen using Arhgef1 (GB111024) at dilution of 1:2000 (400x lens) |
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Immunofluorescence of paraffin embedded rat thymus using Arhgef1 (GB111024) at dilution of 1:2000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
