Your shopping cart is empty!
Anti-p27 KIP 1 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | p27 KIP 1 rabbit polyclonal antibody |
Gene Name: | Cyclin-dependent kinase inhibitor 1B |
Synonyms: | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1, cyclin-dependent kinase inhibitor 1B, cyclin dependent kinase inhibitor 1B |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human p27 KIP 1. |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm, Endosome |
Uniprot ID: | P46527, P46414, O08769 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human | 1:500-1:1500 | breast cancer, colon, colon cancer, fibroadenoma, kidney |
Background
The p27Kip1 gene has a DNA sequence similar to other members of the "Cip/Kip" family which include the p21Cip1/Waf1 and p57Kip2 genes. p27Kip1 can bind to cyclin D either alone, or when complexed to its catalytic subunit CDK4, which inhibits the catalytic activity of Cdk4, preventing Cdk4 from adding phosphate residues to the retinoblastoma (pRb) protein. Increased levels of the p27Kip1 protein typically cause cells to arrest in the G1 phase of the cell cycle.
Images
 |
Immunohistochemistry of paraffin embedded human breast cancer using P27 (GB11517) at dilution of 1:500 (400x lens) |
 |
Immunohistochemistry of paraffin embedded human colon using P27 (GB11517) at dilution of 1:500 (400x lens) |
 |
Immunohistochemistry of paraffin embedded human colon cancer using P27 (GB11517) at dilution of 1:500 (400x lens) |
 |
Immunohistochemistry of paraffin embedded human fibroadenoma using P27 (GB11517) at dilution of 1:500 (400x lens) |
 |
Immunofluorescence of paraffin embedded human kidney using P27 (GB11517) at dilution of 1:500 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
