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| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: |
P38 rabbit polyclonal |
| Gene Name: | Mitogen-activated protein kinase 14 |
| Synonyms: |
MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2,PRKM14,PRKM15, RK, SAPK2A,p38,p38ALPHA, mitogen-activated protein kinase 14 |
| Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse P38 |
| Isotype: | IgG |
| Purity: | Affinity purification |
| Subcellular location: | Cytoplasm, Nucleus |
| Uniprot ID: | Q16539,P47811,P70618 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 1000-1: 2000 | kidney, lung, lung cancer, testis |
Background
MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such asproliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress-related transcription and cell cycle regulation, as well as in genotoxic stress response.
Images
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Immunohistochemistry of paraffin embedded human lung cancer using P38 (GB11005) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse kidney using P38 (GB11005) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse lung using P38 (GB11005) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse testis using P38 (GB11005) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded rat kidney using P38 (GB11005) at dilution of 1:1000 (400x lens) |
| Immunohistochemistry of paraffin embedded rat lung using P38 (GB11005) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded rat testis using P38 (GB11005) at dilution of 1:1000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100μg/ml BSA and 50% glycerol. |
