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Product Category:
Human Adenovirus Type5 (dE1/E3) expressing NEDD4 gene under CMV promoter.
Description:
Neural Precursor Cell Expressed, Developmentally Down-regulated 4
Gene Name:
Neural Precursor Cell Expressed, Developmentally Down-regulated 4
ACCN:
EU832821.1
Gene ID:
4734
GI Number:
190692114
Fusion Tag:
No
Promoter:
CMV
Storage Buffer:
DMEM with 2.5% BSA, 2.5% glycerol
Background:
The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein. It contains one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It is involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. It acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, a paradigm analogous to that of Mdm2 and p53. It is also reported to be involved in the budding of many viruses and is the regulator of epithelial Na+ channels, which lead to arterial hypertension. NEDD4 protein is localized to the sarcolemmal region of muscle fibers. Increase in NEDD4 protein expression leads to unloaded and denervated muscles as well as a decrease in Notch1 expression. Hence it acts as down regulator of Notch-1 gene expression.
Documents:
