Your shopping cart is empty!
| Product Category: | Human Adenovirus Type5 (dE1/E3) expressing NEDD4 gene under CMV promoter. |
| Description: | Neural Precursor Cell Expressed, Developmentally Down-regulated 4 |
| Gene: | Neural Precursor Cell Expressed, Developmentally Down-regulated 4 |
| NCBI Acc. #: | EU832821.1 |
| Gene ID: | 4734 |
| GI Number: | 190692114 |
| Fusion Tag: | No |
| Promoter: | CMV |
| Storage Buffer: | DMEM with 2.5% BSA, 2.5% glycerol |
| Background: | The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein. It contains one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It is involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. It acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, a paradigm analogous to that of Mdm2 and p53. It is also reported to be involved in the budding of many viruses and is the regulator of epithelial Na+ channels, which lead to arterial hypertension. NEDD4 protein is localized to the sarcolemmal region of muscle fibers. Increase in NEDD4 protein expression leads to unloaded and denervated muscles as well as a decrease in Notch1 expression. Hence it acts as down regulator of Notch-1 gene expression. |
| Documents: | Please contact us to request the manual |
