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Product Category:
Human Adenovirus Type5 (dE1/E3) expressing Retinoblastoma-like 1 (p107) (RBL1) under a CMV promoter.
Description:
Retinoblastoma-like 1 (p107), pre-packaged adenovirus, ready to ship and ready to use format.
Gene Name:
Retinoblastoma-like 1 (p107)
ACCN:
BC032247
Gene ID:
5933
GI Number:
21595245
Fusion Tag:
C-terminus V5 epitope
Promoter:
CMV
Titer:
1×1010~1×1011 PFU/ml
Storage Buffer:
DMEM with 2.5% BSA, 2.5% glycerol
Background:
RB-like 1 (RBL1) is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and RB-like 1 can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that RB-like 1 may also be a tumor suppressor.
Storage:
-80°C
Documents:
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