Adenovirus TP53RK (200 µl)

Product Category:

Human Adenovirus Type5 (dE1/E3) expressing TP53 Regulating Kinase (dominant negative format) under a CMV promoter.

Description:

TP53 Regulating Kinase (kinase dead or dominant negative), premade adenovirus, ready to ship and ready to use format.

Gene Name:

TP53 Regulating Kinase (kinase dead or dominant negative)

ACCN:

BC009727

Gene ID:

112858

GI Number:

16307276

Fusion Tag:

C-terminus 6xHN tag

Promoter:

CMV

Mutation:

G217A, A218T, E73M

Titer:

1E+10~1E+11 PFU/ml

Storage Buffer:

DMEM with 2.5% BSA, 2.5% glycerol

Background:

Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806).

Documents:

Manual