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| Product Category: | Human Adenovirus Type5 (dE1/E3) expressing TP53 Regulating Kinase (dominant negative format) under a CMV promoter. |
| Description: | TP53 Regulating Kinase (kinase dead or dominant negative), premade adenovirus, ready to ship and ready to use format. |
| Gene: | TP53 Regulating Kinase (kinase dead or dominant negative) |
| NCBI Acc. #: | BC009727 |
| Gene ID: | 112858 |
| GI Number: | 16307276 |
| Fusion Tag: | C-terminus 6xHN tag |
| Promoter: | CMV |
| Mutation: | G217A, A218T, E73M |
| Titer: | 1E+10~1E+11 PFU/ml |
| Storage Buffer: | DMEM with 2.5% BSA, 2.5% glycerol |
| Background: | Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806). |
| Documents: | Please contact us to request the manual |
